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Sniffing out diseases with a 'bio-electronic' nose

Brussels, 20 Sep 2006

A new EU-funded project aims to develop an artificial, 'bio-electronic' nose which could help doctors to diagnose a range of diseases. State-of-the-art nose technology is currently based on electrical conducting polymers - materials which are similar to plastics but can conduct electricity. These materials can be primed to absorb and respond to different odour molecules, and a typical artificial nose will feature an array of polymer sensors, each of which is responsive to a particular substance. However, odours affect many of the sensors in different ways, and the resulting pattern of responses needs to be analysed. Furthermore, their sensitivity is still relatively low.

The Receptronics project has picked up the scent from a different angle. 'We plan to replicate what goes on in biology,' Prof. Hywel Morgan of the University of Southampton told CORDIS News. In the nose are cells with molecules embedded in the cell membrane. When these bind with an odour molecule, a hole opens in the molecule and an electrical current flows, creating a stimulus, which is transmitted to the brain.

In the Receptronics project, the researchers will use molecular engineering techniques to create receptors which are sensitive to different substances, based on designs found in animal noses. These receptors will be embedded in membranes in an array, with each receptor linked to an electronic interface which can detect electronic signals transmitted when the receptor binds with its target molecule. The system will be mounted on a credit-card sized chip.

According to Professor Morgan, the new nose will have a sensitivity 100 to 1000 times greater than today's electronic noses. The three-year project will focus on designing a system which could be used in medicine to detect hormones, and so help doctors to diagnose a range of diseases.

However, a highly sensitive bio-electronic nose could have applications in a range of areas, such as detecting explosives and determining the freshness of food.

'Most odours are still mapped by humans,' said Morgan. 'If we can find a way to replace this function with technology, we could use odour detection in many new areas.'

The Receptronics project (full name: Label Free Biomolecular Detectors: at the Convergence of Bioengineered Receptors and Microelectronics) links researchers in Italy, the UK, France and Greece and has sniffed-out €1.99 million in funding under the Sixth Framework Programme.

Further information:
http://cordis.europa.eu/fetch?CALLER=FP6_PROJ&ACTION=D&RCN=74953

Cordis
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Readers' comments (1)

  • There already is a highly developed Bio Electronic Diagnostic System available. It has been in existence for around seventy years. European countries use it as a matterof course, as doctors and homeopaths are trained this way. It is a highly valuable tool and the fact a chore group within the British Medical Establishment had it banned in this country stretches the boundaries of human decency.

    I use this machine after learning of it's existence when I became chronically ill. It has the capacity to detect/ treat the origins of the diseases affecting children (and adults) today. The most common factor being congenital, as I learned. It's capabilities in the field of curative medicine are awesome. Why then was it banned?

    The explosion of chronic illnessess have blighted the lives of so many, yet it doesn't have to be like that. In my early days as a nurse we never saw a fraction of the epidemic we are seeing today. It is a travest this type of truly remarkable medicine is banned in this country.

    Holland is only one country where there is a three year university course of such.

    Perhaps THES might like to take an interest and encourage the same in this country? How many of us don't know someone (at least) who is prematurely ill?

    It is a travesty?

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